Biology Education

Department of Biology | Lund University

Complex Genomes in Cancer

We use whole-genome and whole-transcriptome sequencing data from primary cancer samples to elucidate genetic subgroups of potential clinical relevance. Our next step will be to identify mutational signatures on the single-nucleotide, copy number and structural variant levels. To do so, multiple variant callers will be used, their output consolidated into a consensus list of variants per case, and then signature profilers will extract and annotate relevant mutational signatures. The project would entail setting up a pipeline that can generate variant call format (vcf) files from ready-mapped whole-genome sequencing data, match the output of multiple variant callers within each category of mutations and then apply signature extraction tools.

Contacts:

Karolin Hansén Nord PhD,  karolin.hansen_nord@med.lu.se

Associate Professor, Senior Lecturer

 

Karim H. Saba PhD

Associate Researcher

 

Division of Clinical Genetics

Department of Laboratory Medicine

Faculty of Medicine

Lund University

Web page Complex Genomes in Cancer

December 11, 2024

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Bioinformatics