The conventional wisdom linking high genetic diversity with population viability is increasingly scrutinized, as empirical evidence shows that some species can persist despite low genetic diversity. This problem raises questions about alternative genomic factors that might compensate for limited traditional genetic variation. Our project seeks to unravel these mysteries by examining how genetic redundancy through duplicated sequences, like orthologs, and the role of non-coding elements such as transposable elements (TEs), contribute to species resilience during and after population bottlenecks.
The project will explore the hypothesis that duplicated sequences offer genetic redundancy, potentially crucial for survival post-bottleneck, by providing backup gene copies for essential functions or evolving new ones. Furthermore, the adaptive role of TEs under post-bottleneck selective pressures, facilitating recovery and adaptation, will also be a significant focus.
Data for this research includes hundreds of re-sequenced genomes from three endangered species, complemented by chromosome-level assemblies, offering a robust foundation for comprehensive genomic analyses.
Profile: We are seeking a student with a strong background in bioinformatics, coupled with a keen interest and a solid understanding of population genetics and evolutionary genomics. This project offers a unique opportunity to be at the forefront of exploring the intricate dynamics of genetic resilience, potentially reshaping our understanding of biodiversity conservation.
Contact: Hernán E. Morales, hernan.morales@biol.lu.se