Project duration
From 10 to 12 months starting in term 2023 autumn – 2024 spring
Project description
The aim of this project is to identify novel regulators of the ubiquitin-proteasomal patway in leukemia. The thesis work would focus on identification of genes that are essential for the optimal functioning of the ubiquitin-proteasomal system in leukemic cells. Identified gene candidates will be studied further in the context of determining sensitivity of protein degrader drugs which are currently emerging as alternative therapies for leukemia.
Requirements for candidate
- Experience in vector cloning or cell culturing
- Experience in standard molecular assays (western blot, RT-qPCR and others)
The project includes
- Gene knockout using CRISPR
- FACS assays
- Gene expression and genome accessibility assays
- Assays related to ubiquitin-proteasome system
- Possibility to work with primary human hematopoietic stem cells.
Supervisor: Agatheeswaran Subramaniam, PhD
More information about the PI:
Please send your CV and a short motivational letter before May 31, 2023.
to agatheeswaran.subramaniam@med.lu.se , with topic “Master thesis project”.
You can also contact Agathees for any questions or more information on the position.