DNA molecules in our cells are packaged around histone proteins to form a structure called chromatin, which preserves cell function. Chromatin contains so-called epigenetic information (for example, in the form of post-translational modifications of histones) that safeguards transcriptional programs and promotes genomic stability. Unsurprisingly, mutations in chromatin proteins and alterations of epigenetic information disrupt cellular processes and contribute to human disease.
How do epigenetic alterations cause human disease?
In our lab, we model disease-associated epigenetic aberrations in human cells, with the aim of understanding how these aberrations affect DNA repair, gene transcription, and cell division. The methods employed include human cell culture, advanced molecular biology and biochemistry, genomics, and high-content microscopy.
I am looking for a highly motivated master’s student to undertake a wet lab project. Interest in chromatin biology and epigenetics, transcription, and/or DNA repair is essential for the project.
You will be joining a newly formed lab, embedded in a stimulating research environment at BMC A11, and benefit from regular hands-on supervision from the group leader (Giulia Saredi). The project will ideally start in the autumn term, with a recommended length of 60 credits.
If you have any questions on the project, please contact me (g.saredi[at]dundee.ac.uk) and include a brief description of why you’re interested in joining the lab.