Diabetes is a multi-organ disease which is heterogeneous in manifestation. Our group discovered 5 subtypes of diabetes in the Swedish ANDIS study that showed …
Posts in Bioinformatics
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Today we have the technology to identify almost any genetic alteration in cancer genomes. However, we still lack efficient bioinformatic tools that can help …
SupervisorsMaria Swanberg, Senior Lecturer in Translational Neuroscience Kajsa Atterling Brolin, Postdoctoral Fellow PlacementTranslational Neurogenetics Unit, Wallenberg Neuroscience Center, BMC, Lund https://portal.research.lu.se/en/organisations/translational-neurogenetics Project descriptionParkinson’s disease …
Molecular neuroscience has largely focused on the functions of protein-coding genes, which account for less than 2% of our DNA. Repetitive elements – including …
The tumor microenvironment (TME) is a complex and dynamic landscape that plays a pivotal role in the progression and behavior of cancer. Comprising various …
Alzheimer’s disease (AD), one of the most common forms of dementia, constitutes a high social and economic burden expected to increase in the upcoming …
It is well-established that innate immunity plays a significant role in responding to and influencing the progression of Alzheimer’s disease (AD) (Heneka et al., …
In cellular environment protein abundance and half-life are determined by ubiquitin-proteasomal system. Ubiquitin ligases recognize a highly specific peptide motif (degron) and transfer polyubiquitin …
The COVID-19 pandemic has highlighted sex differences during infection, with increased hospitalizations and deaths in SARS-CoV-2-infected men as compared to women. This observation is …
Modern genomics methods produce vast amounts of genetic data, but we have limited ability to interpret the effects of sequence variation on gene expression, …
While recent research has improved treatment of primary tumours, few discoveries have specifically benefited patients with metastatic disease such as brain metastases. The microenvironment …
The project aims to investigate the transcriptional differences between intestinal organoids cultured under normoxic (21% O2) and hypoxic (1-5% O2) conditions, with a particular …
The conventional wisdom linking high genetic diversity with population viability is increasingly scrutinized, as empirical evidence shows that some species can persist despite low …
The study of deleterious variation, or genetic load, in natural populations has become increasingly important in conservation genomics, particularly with the advent of novel …
In population genetics, making an accurate calling and phasing of genetic variants is crucial, but it is often a non-trivial challenge, especially for non-model …
We have previously found empirical evidence for antagonistic coevolution between the sex chromosomes in Drosophila melanogaster (see Lund-Hansen et al 2021, https://www.pnas.org/doi/full/10.1073/pnas.2003359118) and are …
Salamanders are the only vertebrates able to regenerate their limbs. The cellular mechanisms that enable this remarkable process are just beginning to be elucidated. …
The intriguing realm of porifera, known as sponges, beckons exploration in molecular biology. As among the most primitive multicellular organisms, sponges provide crucial insights …
The dynamic world of porifera, commonly known as sponges, presents a captivating avenue for exploration within molecular biology. Sponges, considered among the most primitive …
Do you want to contribute to a better understanding of the mechanisms that underpin the diversification of species and the phylogenetic structure of emerging …