Biology Education

Department of Biology | Lund University

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How polymorphic retrotransposons influence gene expression in pluripotent stem cells and early brain development

Molecular neuroscience has largely focused on the functions of protein-coding genes, which account for less than 2% of our DNA. Genomic repeats – including viral-like sequences called retrotransposons – comprise around half of the human genome, but limitations in sequencing technologies and other molecular tools have left many repeats overlooked – so-called ‘genomic dark matter’. This is an important mechanistic blind spot: repeats are dynamic stretches of DNA that can mobilise or duplicate, and impact transcriptional programs. Repeats are the main source of individual genetic variation. When their dynamics are not controlled, repeats cause severe neurological disorders.

In the Lab of Epigenetics and Chromatin Dynamics (https://www.stemcellcenter.lu.se/research-groups/douse) we are interested in how this genomic dark matter is controlled by epigenetic mechanisms during human brain development. We have a particular focus on how different protein complexes package repetitive DNA into chromatin, and how chromatin influences transcriptional dynamics. We combine chromatin biochemistry with functional (epi)genomics in human stem cell models.

In this project you will characterize how tandem and interspersed repeats shape epigenetic and transcriptomic landscapes within a defined genetic background. By employing CRISPRi and/or CRISPRa to systematically dysregulate controlling pathways, we will generate pluripotent stem cell lines that exhibit an accumulation of either retrotransposons or tandem repeats. This will facilitate a comparative analysis, offering a “magnified” view of repeat-driven effects from the parental lineage. Epigenetic, transcriptomic landscape and the ability to differentiate to the neural lineage will be investigated and compared between accumulation and parental cell lines.

Our lab is based in a dynamic, collaborative and friendly environment at BMC A11 and we have space for 1 MS student. The project would start in the autumn term but we are open to later start dates e.g. if there are additional courses that the student would like to take to prepare. We are also open to designing thesis projects that are wet-lab-only or a combination of wet and dry lab. For the latter, it would be necessary that you have at least some knowledge of how to run basic operations from a command line.

If you have any questions you are welcome to email me (Chris) directly at christopher.douse@med.lu.se – please include a brief description of why you’re interested and attach a CV, grade transcript (if available) and details of 1-2 previous supervisors or mentors who could provide a reference.

 

*Please be aware that we would like to have the student(s) lined up well in advance of the summer break 2026. If you are interested in starting the project earlier or during the summer, let us know.*

March 26, 2026

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Molecular Biology

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Fungi self healing concrete

Main goal: The main goal of the project is to understand how pore scale fungal calcium carbonate precipitation contributes to material properties.

Description:

Concrete is the world’s most widely used human-made material, yet its production is responsible for significant environmental impacts: generation of hazardous airborne dust, high energy consumption, and substantial CO₂ emissions. Given the impracticality of replacing concrete, our study proposes a sustainable alternative—concrete crack healing using fungi—to prevent reinforcement corrosion and thereby extend structural service life, ultimately reducing carbon output.

The method using fungi to repair cracks involves Microbial-Induced Calcium Carbonate Precipitation (MICP). MICP is a natural process in which microorganisms precipitate calcium carbonate (CaCO₃), thereby sealing cracks and reinforcing concrete surfaces

Because cement-based materials are opaque, directly observing microbial growth and mineral precipitation within cracks is challenging. To address this, we will use a high-resolution 3D X-ray microscope to visualize fungal mycelium development and calcium carbonate precipitation in porous materials. This imaging approach will help reveal how pore-scale biological processes contribute to the overall properties and durability of the material.

As part of this project, you will work with fungal bioreactor and high resolution 3D x-ray tomograph. Training in all of these techniques will be provided. The candidate must be proficient in standard microbiological methods, including sterile inoculation and nutrient medium preparation.

This project is interdisciplinary task within biology and engineering. You will primarily work with Dr. Hanbang Zou. This project is designed for a MSc student (optimal 60 cr).

Start Date: Flexible

Contact information:

Hanbang Zou: Hanbang.zou@biol.lu.se

March 16, 2026

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Biology

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Monitoring natural populations of pied and collared flycatchers

Join Our Field Research Team This Spring on Öland! 🌿🐦

We are looking for up to two enthusiastic internship students to join us for a two-month field season exploring evolutionary ecology, sensory ecology, and climate change.

You’ll become part of our team monitoring natural populations of pied and collared flycatchers, including their hybrids, on the beautiful Swedish island of Öland, near Kalmar.

Position Details:

  • 📍 Location: Öland, Sweden
  • 📅 Dates: Field season runs May 1 – July 1. We prefer you to be there the whole season, with arrival on site between April 26 and May 1.
  • 👥 Positions: 2 interns (internship or applied work)
  • 🏛️ Institution: Uppsala University (open to students from Lund University)

This year’s activities include:

• Fieldwork & Data Collection – Monitor nest boxes, ring and measure chicks, and collect blood samples as part of our long-term population study
• Behavioral Assays – Conduct cognitive tests with individual birds near nest boxes and in aviaries using standardized research methods
• Foraging Ecology – Analyse behavioural data and explore links between individual performance and foraging preferences in caterpillar-rich trees
• Field Observations – Set up remote video cameras to document bird visitation rates to individual trees
• Chemical Sampling – Collect branch samples for later analysis of IH-BVOCs

Depending on the length and timing of your internship, there may also be opportunities for lab work.

This is a unique chance to gain serious hands-on research experience, contribute to ongoing research, and spend your spring outdoors.

Interested? Get in touch!

Michaëla Berdougo (PhD student) – michaela.berdougo@ebc.uu.se

Read more about the Qvarnström lab

March 13, 2026

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Biology

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Does tissue hypoxia affect RNA editing in cancer cells?

I’m looking for a highly motivated Molecular Biology Master student to join my group, preferably for a longer project (45 or 60 credits). Prior experience with cell culture, RNA work, PCRs, or microscopy would be a big plus.

Research project

One of the most common RNA modifications in human cells is A-to-I RNA editing, which refers to the deamination of adenosine bases by ADAR enzymes, forming inosine, which chemically resembles guanosine in its base-pairing properties. If this rewriting of the letter “A” to the letter “I” occurs in a coding region of an mRNA, it can function like an A-to-G mutation on the RNA level, recoding a protein; if it happens in one of the many repetitive elements found in non-coding regions of RNA, it can regulate innate immunity; and if a non-coding RNA is edited, it can regulate its ability to form structures or select targets. Even though ADAR enzymes are naturally found in all human cells, and A-to-I RNA editing is normal and needed in a healthy individual, the deregulation of A-to-I RNA editing has been linked to numerous diseases, including cancer.

Research in my group focuses on how the deregulation of A-to-I RNA editing is linked to differences in the tumor microenvironment. Focusing on differential oxygenation, we want to understand how tumor hypoxia affects A-to-I editing in cancer cells. You will grow cancer cell lines at different oxygen levels and assess the levels of RNA editing using different assays, such as luciferase assays, RT-PCR, Sanger sequencing, and immunofluorescence. Depending on your interests and prior experience, you could also contribute to establishing new assays in the lab, such as 3D cell culture.

Contact:

Gjendine Voss (gjendine.voss@med.lu.se)

Department of Experimental Medical Science, Faculty of Medicine

March 12, 2026

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Molecular Biology

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Landscape composition for supporting pollinators and implications for conservation

We are seeking a Master’s student for a 30, 45, or 60 credit thesis opportunity starting Summer 2026 to explore habitat-sharing among wild pollinators in a flower-rich Swedish landscape and what this means for landscape management.

Background:

Plant-pollinator networks are typically limited to within-habitat interactions and rarely consider habitat-sharing among pollinators, or how networks are affected by plant-pollinator relationships in the surrounding landscape. The likelihood of a pollinator foraging in different habitats can be influenced by the available forage, species-specific traits, competition, or environmental conditions. By understanding how habitat use is mediated we can shape landscape conservation efforts around the ability of pollinators to move about their surroundings.

Project description:

As part of VALOR, a Horizon EU project, we will undertake transects of plants and pollinators in a Swedish landscape comprised of at least three habitats: semi-natural grassland, pollinator-dependent crops, and field margins.

The student will contribute by conducting transects and sampling at least two focal pollinator species and swabbing them for body pollen. They will then analyze the body pollen using machine learning techniques available at Lund University, comparing body pollen composition with plant surveys conducted in the field, and determining how this comparison changes with pollinator traits and environmental variables.

Work on this project will help develop field sampling and laboratory skills as well as equipping any student with experience in shaping research questions, data analysis, and scientific writing in conservation and ecology.

Are you interested? To enquire about this position, please contact Arrian Karbassioon (arrian.karbassioon@mgeo.lu.se) and Richard Walters (richard.walters@mgeo.lu.se) for more information.

March 10, 2026

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Biology

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Simulating how pollinator losses affect wild plant reproduction

We are seeking a Master’s student for a 30, 45, or 60 credit thesis opportunity starting Spring / Summer 2026 to explore the relationship between pollinator visitation, seed set, and seed viability. Work schedule is flexible and will involve seed counting and the possibility to conduct germination tests

Background:

While there is good understanding of the negative consequences of pollinator declines for crops, we know very little about the effects on wild plant communities. Wild plant communities are thought to be more resilient to changes in pollinator assemblages than crops because they contain different traits and variation in their responses to fluctuation. Such variation arises from the differential dependence of plant species to rely on pollinators for reproduction. However, it is predicted yet barely known whether these differences on pollinator dependence can maintain overall plant diversity but significantly shift plant composition.

Project description:

To address this gap, we have already manipulated pollinator visitation to three wild plant species of varying pollinator dependence (low, medium and obligate insect pollinated). A subset of these pollinators has been sampled for pollen which has been identified using machine learning techniques. In addition, we have sampled seeds from all three wild plant species to determine if pollination success is related to visitation and / or body pollen.

The student will contribute to the project by counting and measuring seeds utilizing automated software, and possibly conducting germination tests on a subset of seeds for additional credits.

Using these data, the student will determine how pollen limitation, or variation expected in climate or land use scenarios, determines pollination services. Working on this project will help develop laboratory and data collection skills, as well as experience with analytical tools and scientific writing.

Are you interested?

If you would like to know more about this position and working with insect pollinators, please contact Arrian Karbassioon (arrian.karbassioon@mgeo.lu.se) and Richard Walters (richard.walters@mgeo.lu.se) for more information.

March 10, 2026

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Biology

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Using biologging devices to study the movement of sick birds

Much like us, when a bird is sick, it reduces activity, stops eating and loses weight. This is a core part of the immune response, helping to conserve energy and fight the infection. It also reduces the change of transmitting infection to other birds. However, if birds are exposed to repeated infections, it may no longer be beneficial to have repeated bouts of fasting and inactivity.

Bird feeders could be a source of infection, and birds that visit feeders could be exposed to repeated infections at feeders. In turn, these birds are expected to be better able to cope with sickness and continue to be active while sick, which could increase the chances of transmitting infection to other birds and becoming ‘superspreaders’.

Activity loggers (accelerometers), placed on the back of the bird, allow the remote study of activity and behaviour, by measuring acceleration. To be able to distinguish different behaviours from the acceleration data, we can film birds while carrying loggers so we can link specific behaviours to unique acceleration profiles. The student will, firstly, annotate videos of birds to pair behaviours – such as flying, resting, eating, or preening – with the corresponding acceleration data. A behavioural classification model (using supervised machine learning methods) built on this data will then be applied to acceleration data from birds who have been exposed to a simulated infection.

In this project, the student will gain core skills in data handling and analysis in R and learn about movement ecology, immune function and avian ecology.

 

Contact Hannah Watson for more details: hannah.watson@biol.lu.se

https://portal.research.lu.se/en/persons/hannah-watson/

 

If you want to know more…

Yu et al. 2024. Flight activity ad effort of breeding pied flycatchers in the wild, revealed with accelerometers and machine learning. Journal of Experimental Biology, 227:jeb247606. https://doi.org/10.1242/jeb.247606

Yu et al. 2023. Accelerometer sampling requirements for animal behaviour classification and estimation for energy expenditure. Animal Biotelemetry, 11:28. https://doi.org/10.1186/s40317-023-00339-w

February 18, 2026

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Biology

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Rewilding from a beetle perspective

I am searching for a master student that would like to do their master thesis project with me, possibly Ola Olsson, and Anne-Maarit Hekkala (SLU Umeå). The project will be on how long-horned beetles are affected by Swedish Ecoparks, e.g. multifunctional forest landscapes (landscapes that include a multitude of management practices), forest structures, and rewilding practices. The focus areas of the project are in Kalmar and close to Umeå. Some fieldwork to measure forest structures will be included in the project.

For this project we are searching for a master student that:

  • Wants to do a 45-60 hp thesis project.
  • Can start this year.
  • Would like to do some fieldwork (mostly independently).
  • Has preferably some experience in R (or is willing to learn more about R).
  • Is eager to understand how we can protect long-horned beetles in forest ecosystems.

Does this sound like something for you?

Email me for more information: lydwin_freija.wagenaar@biol.lu.se

February 18, 2026

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Biology

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Inside an owl: microbiomes and health of a top predator

Increasing evidence suggests that the community of microbes located within the gastrointestinal tract of vertebrates – the “gut microbiome” – is a crucial determinant of health and physiological condition. However, the factors shaping the gut microbiome, especially during early life, are poorly understood.

The tawny owl is one of our most common predators occurring in urban, agricultural and forest habitats. It is a generalist predator, and the diet can vary between nests and years.

The overall aim of the project is to characterise the gut microbiome of young and adult tawny owls and investigate the causes and consequences of variation in the microbiome. There are several questions that could be addressed including:

  • How does the gut microbiome vary across a gradient of human modification of the landscape?
  • How does diet shape the gut microbiome?
  • Can the gut microbiome indicate quality of an individual and the likelihood of a chick recruiting into the breeding population?
  • How does the gut microbiome change during development and relate to chick growth?
  • How similar are the gut microbiomes of parents and offspring?

The project would suit a student with an interest in evolutionary and molecular ecology and with some previous experience of R. The student will employ bioinformatics approaches to process DNA sequence data and carry out multivariate analyses in R. Depending on the stage of joining the project, there may be labwork.

Contact Hannah Watson for more details: hannah.watson@biol.lu.se

https://portal.research.lu.se/en/persons/hannah-watson/

If you want to read more…

Bodawatta et al. 2022. Avian gut microbiomes taking flight. Trends in Microbiology. 10.1016/j.tim.2021.07.003

Corl A et al. 2020. Movement ecology and sex are linked to barn owl microbial community composition. Molecular Ecology 29:1358-1371. 10.1111/mec.15398

Videvall E et al. 2019. Major shifts in gut microbiota during development and its relationship to growth in ostriches. Molecular Ecology 28:2653-2667. 10.1111/mec.15087

February 17, 2026

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Biology Molecular Biology

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Climate Change in the Arctic: Direct and Indirect Effects of Warming on Microbial Thermal Traits

Climate warming is especially pronounced in Arctic regions, where ecosystems are experiencing stronger and faster changes than the global average. This leads not only to rising temperatures but also to more frequent and intense extreme events, such as heat waves and droughts. Arctic soil microbes are directly affected by warming and indirectly influenced through changes in plant inputs and soil moisture. Microbial communities are central to ecosystem functions, including carbon and nutrient cycling, yet we still lack detailed knowledge of how warming and its indirect effects—such as drought and altered litter inputs—shape microbial thermal traits and activity. This project aims to address this knowledge gap using field warming experiments in Abisko, Sweden.

Supervisors: Honorine Dumontel & Johannes Rousk

Objectives

We are establishing field experiments to test how warming affects microbial thermal traits and how indirect warming effects—such as changes in plant inputs and drought—modulate microbial responses. We will study these effects using a soil warming experiment in Abisko, northern Sweden: AWRORE (Arctic Warming Responses to Organic matter and Reduced precipitation Experiment).

Here, many interesting thesis questions could be posed, potential research questions include:

  • How do direct warming effects and indirect effects (drought and/or litter addition) shift microbial thermal traits? Do these changes alter microbial nutrient limitation?
  • Are shifts in microbial thermal traits driven more strongly by temperature itself or by warming-induced changes in substrate availability?
  • Does reduced precipitation modify microbial temperature responses under summer warming?
  • Does warming influence microbial litter decomposition and associated carbon cycling processes?
  • How do drying–rewetting events affect microbial growth and respiration across different warming treatments?
  • Does prior exposure to warming alter microbial resistance or resilience to drying–rewetting pulses?
  • Above-belowground interactions : How do warming-induced changes in soil microbes influence plant–microbe interactions?

The main things we will test are microbial temperature responses (growth and respiration) under a range of field treatments that combine seasonal effects (summer, winter, and chronic warming), drought, warming intensity (summer vs. extreme summer warming), and litter addition.

We will be very interested in talking more about your own questions and interest to developed a project.

 

Skills and techniques acquired

  • Field work (setup the warming experiment, sampling, NDVI and LiCor measurements)
  • Measuring bacterial and fungal growth rates using isotope tracing
  • Estimating soil respiration using gas chromatography
  • Soil physicochemical analyses (moisture, C, N, pH, organic matter, etc.)
  • Assess microbial community composition
  • Search and compile relevant literature within the topic
  • Data processing and statistical analysis

 

 

Master’s Thesis Timeline (Field and Laboratory Work)

June 2026: Fieldwork in Abisko – experiment setup, sampling, and measurements (1 week); lab work on bacterial temperature dependences (~2 weeks)

July 2026: Fieldwork in Abisko – sampling and measurements (1 week); lab work on bacterial temperature dependences (~2 weeks)

August 2026: Fieldwork in Abisko – experiment setup, sampling, and measurements (1 week); lab incubation and measurements of bacteria, fungi, and respiration temperature dependences (~1 month)

Autumn 2026. Thesis.

 

Required knowledge

Strong interest in soil and microbial ecology. No prior experience required; training will be provided.

 

Application process

If you are interested, please contact: Honorine Dumontel, honorine.dumontel@biol.lu.se and/or Johannes Rousk, johannes.rousk@biol.lu.se

 

February 12, 2026

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Biology

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